题  目🧛🏽‍♀️：DNA甲基化调控的结构基础

报告人：徐彦辉 研究员

主持人：翁杰敏 教授

时  间🪇：2015年10月9日下午13:30 -15:00 （周五下午）

地  点👆🧕🏽：闵行校区天美娱乐534报告厅

 

报告人简介🚝：徐彦辉，复旦大学，研究员，博士生导师。主要开展表观遗传调控关键蛋白的结构与功能🫱🏿。系统的阐明了DNA甲基化🧑🏻‍🦰，去甲基化关键蛋白酶发挥功能的分子机制。在国际上率先报道了TET2-DNA复合物的晶体结构📐，发现并揭示DNA甲基转移酶DNMT3A存在自我抑制并揭示及其被组蛋白H3激活的机制，系统的研究了维持型DNA甲基化关键蛋白DNMT1和UHRF1的结构与功能。研究工作发表在包括Cell，Nature，Mol Cell，Genes & Dev等杂志，2010年以来发表通讯作者论文20余篇。入选2014年“国家杰出青年科学基金”👩‍✈️🕖，入选中组部“青年拔尖人才”🦸🏻，上海市“优秀学术带头人”🏃🏻‍♀️‍➡️👧🏼，获上海市“青年科技英才奖”等奖项。课题组网页：http://xtal.fudan.edu.cn

 

报告内容简介🚔：The Xu Lab takes biochemical and structural approaches to investigate the molecular mechanisms of marcomolecules that are involved in epigenetic regulation and transcription. We are interested in the mechanisms for catalysis, substrate recognition, and regulation of enzymatic activities of proteins for DNA methylation (DNMTs, UHRF1, TET1/2/3), histone methylation (LSD1/2, JmjCs), the cross-talk between DNA methylation and histone methylation. We just started to pay attention to the proteins involved in RNA methylaton. We are also interested in the mechanism for tumorigenesis. We study the key regulators (HKDM, DNMTs, Hippo, mTOR pathways) to reveal their role in tumorigenesis and provide structural basis for potential drug targets.

Our lab also takes advantage of the structural findings to design and screen inhibitors for research and potential therapeutic applications.